Pietro Gentile, Rubina Alvesc John P. Colee, Katarina Andjelkov, Thierry Van Helmelryck, Jonathan Fernandez, Angelo Trivisonno, Lemierre Guillaume, Alexis Verpaele, Patrick Tonnard, Jeremy Magalon, Guy Magalon, and Sophie Menkes

ABSTRACT

Introduction: Many investigations showed that platelet-rich plasma (PRP), human follicle stem cells (HFSCs), and adipose-derived stem cells (ASCs), considered autologous stem cell-based therapy (ASCBT), are effective for hair regrowth (HR) in patients affected by androgenetic alopecia and for wound healing (WH). This article analyzes the in vitro and in vivo impact of PRP, HFSCs, and ASCs preparation methods on HR and WH.

Areas Covered: The analyzed data is intended to clarify the molecular mechanism in which PRP, HFSCs, and ASCs are involved, as well as the clinical use and related indications, fully respecting the European rules. Comparative studies between different PRP, HFSCs, and ASCs preparation systems revealed differences in HR and WH.

Expert Opinion: Despite a lack of standardized protocols, there is convincing evidence with objective measurement modalities that display positive outcomes of ASC-BT in HR and WH.